Rabat – The death toll in the Italian earthquake has risen to at least 247 as thousands of rescuers continue efforts to find survivors, local authorities said on Thursday morning.Dozens are believed trapped in ruined Amatrice, Accumoli and Pescara del Tronto, in mountainous central Italy.The search went on through the night, and there was a strong aftershock which rocked already damaged buildings. More than 4,300 rescuers are using heavy lifting equipment and their bare hands.Many of the victims were children, the health minister said, and there were warnings the toll could rise further.The 6.2-magnitude quake hit at 01:36 GMT on Wednesday 100km (65 miles) north-east of Rome.With MAP
A UN spokesman told reporters on Friday afternoon that outstanding provisions still under negotiation in the draft plan included measures relating to export controls and conference review meetings. Another key area under discussion, according to diplomats attending the two-week forum, is the provision of small arms and light weapons to non-State actors. One major country was seeking to ensure that no restrictions were placed on such transactions, while a number of African States viewed the provision of small arms and light weapons to non-State actors as a highly destabilizing factor which must be addressed, the diplomats said.The draft plan does not aim to outlaw the legal manufacture or trade of small arms and light weapons, nor their legal, private ownership. Instead, it is designed to stem the illicit trade in these armaments, which the UN says were the weapon of choice in the overwhelming majority of recent conflicts that collectively killed some 4 million people, 80 per cent of them women and children.The draft is comprised of four parts, including a preamble and sections on preventing, combating and eradicating the illicit trade in small arms and light weapons; implementation, international cooperation and assistance; and follow-up.
“A credible appeals process is an essential part of fair-trial guarantees,” UN High Commissioner for Human Rights Louise Arbour said in a statement issued yesterday. “This is particularly important in this instance, in which the death penalty has been imposed.“Those convicted today should have every opportunity to exhaust their appellate remedies in a fair way, and whatever the outcome of an appeal, I hope the Government will observe a moratorium on executions,” she added.Ms. Arbour said guaranteeing the right to a fair trial of persons accused of major human rights violations was key to consolidating and strengthening the very important process of ensuring justice and countering impunity that Iraq had embarked upon.Also reacting to the verdict was Leandro Despouy, an unpaid, independent expert serving in his personal capacity as the UN Special Rapporteur on the independence of judges and lawyers, who voiced “strong objections” regarding the conduct of the trial and concern about the consequences the judgment may have in Iraq and the wider region.In a statement, he said the personal jurisdiction of the tribunal was restricted, enabling it only to try Iraqis, and noted also that the body has no mandate to address “the war crimes committed by foreign troops during the first Gulf war (1990), nor the war crimes committed after 1 May 2003, date of the beginning of the occupation.”Mr. Despouy also voiced doubts about the tribunal’s legitimacy and credibility. “The tribunal has been established during an occupation considered by many as illegal, is composed of judges who have been selected during this occupation, including non Iraqi citizens, and has been mainly financed by the United States,” he said.The expert called attention to the negative impact of the violence and insecurity prevailing during the trial. “Since its beginning one of the judges, five candidate judges, three defence lawyers and an employee of the tribunal have been killed,” he noted, while another employee has been seriously injured.Above all, he cited the “lack of observance of a legal framework that conforms to international human rights principles and standards, in particular the right to be tried by an independent and impartial tribunal which upholds the right to a defence.”At the same time, he welcomed Iraq’s determination to sanction the main authors of the atrocities committed during three decades in the country and its will to see the trial take place in Iraq. But he cautioned that “this will be expressed through a trial conducted by an independent tribunal, legitimately established, acting in absolute transparency and providing all guarantees for a fair trial, in accordance with international human rights standards.”If those conditions are not fulfilled, he warned that the Iraqi High Tribunal’s ruling “risks being seen as the expression of the verdict of the winners over the losers.”The Special Rapporteur urged the Iraqi authorities not to carry out the death sentences imposed, saying this would represent a “serious legal setback for the country” while standing in open contradiction to the growing international tendency to abolish capital punishment.“It is clear that the verdict and its possible application will contribute to deepening the armed violence and the political and religious polarization in Iraq, bringing with it the almost certain risk that the crisis will spread to the entire region,” he said.Stressing the significance of the trial of Saddam Hussein, the Special Rapporteur reiterated his proposal for the establishment of an independent, impartial and international tribunal with all the necessary guarantees to enable it to receive the support of the UN.
The Royal Mail says its 2019 Special Stamp programme is supposed to commemorate anniversaries and celebrate events and popular culture relevant to UK heritage and life. Images such as birds of prey and scenes depicting British engineering excellence are planned, as well as six stamps of Queen Victoria at various stages in her life, and four of her husband Prince Albert.The D-Day landings were to be marked with a set of 11 stamps, in what the Royal Mail said “will be a timely commemoration of all those who participated and will use images from the day itself”.Paul Woodadge, 49, a D-Day historian and former tour guide living in Normandy, told the BBC: “It’s quite shocking really. It’s going to be the 75th anniversary of D-Day – the last one where there’s any veterans around who will remember it.”These stamps are the kind of thing people will buy for their fathers and grandfathers.”A Royal Mail spokeswoman said: “We work very hard to ensure that our Special Stamp programme appropriately commemorates anniversaries and events that are relevant to UK heritage and life. “We would like to offer our sincere apologies that our preview release for our 2019 Special Stamp programme included a stamp design which had been incorrectly associated with the D-Day landings.”We can confirm that this image will not be part of the final set, which will be issued in June 2019.” Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. The D-Day landings occurred almost a month later – and thousands of miles away – on the coast of northern France, in what was to be the start of the final allied effort from the West against Nazi-occupied Europe. British Commandos of 1st Special Service Brigade landing from an LCI(S) (Landing Craft Infantry (Small)) on ‘Queen Red’ Beach, SWORD Area, at la Breche, at approximately 8.40 am, 6 June 1944. Credit: IWM/Getty Images Royal Mail has been widely criticised for planning to release a stamp marking the 75th anniversary of D-Day using an image of US troops landing in what was Dutch New Guinea, almost 8,500 miles from the Normandy beaches.The stamps, priced at £1.25 each, were due to be released in 2019 as part of a ‘Best of British’ collection.Captioned ‘Allied soldiers and medics wade ashore’, the image was supposed to depict the amphibious landings on the coast of northern France on June 6, 1944. However, after being previewed on social media, many observers pointed out the geographic error.One commentator on Twitter called it a “disrespectful sloppy blunder” while another said: “Having worked 3 years for Royal Mail, this does not surprise me at all”. Another tweet pointed out that the Royal Mail had released a series of stamps in 1994 commemorating 50 years since the landings, with correct imagery.The image, an official US Coast Guard photo, appears on the website of The National WWII Museum, an American site containing thousands of photographs and oral histories of the war.It first appeared in the July 1944 edition of ‘All Hands’ magazine and clearly states it shows troops carrying stretchers from a landing craft at Sarmi, Dutch New Guinea – now part of Indonesia – on May 17, 1944.
Related Items:damian wilson, leadership, tci patriots Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 28 Jan 2016LIFE – Leadership, Integrity, Fraternity, and EducationHOPE – Help Our People ExcelPOWER – Possessing Our Wealth, Economy and ResourcesWhat is leadership?What is leadership?The above question sounds simple enough, and when answering many will tell you that leadership is simply being in charge or in command, being the one to make the decisions. While this is absolutely true, we must understand that leadership is so much more than that. While the word ‘leadership’ holds simple conations for most, it means much more than simply being in charge or making decisions. We must understand that there are effective leaders and there are those in a position of leadership; they are not necessarily the same thing. You see, the difference here is position versus purpose. What do I mean by this?Often times many persons are given a position where they are in charge of others. However, there hearts have no desire for progress or change, so they keep doing the same things that have always been done. It’s not that they’re not capable but they have not developed a desire for purpose in that role. They may have a lot going on but their actions doesn’t give inspiration to those around them, and therefore, they struggle to gain momentum in their leadership.What we must understand is that leadership isn’t just about the leader, but also about the people they lead. As a leader you will develop a purpose for your leadership by having a heart for the people that you lead. Real effective leadership isn’t about getting people to confirm to your way but about transforming people’s faith in their own abilities through your vision. Successful people identify what they do well; but successful leaders identify what others do well.Aside from the above, I firmly believe that there are a few more key characteristics that any leader should have. Some of these key characteristics are:1. Innovation: Leadership is about introducing something new or different that hasn’t been seen before or taking something already existing or established and transforming it into something new or different. Good leadership is creative and transformative. Innovation in leadership is a process which takes time.2. Decisiveness: A leader must not be afraid to make decisions. Sometimes those decisions will be very hard choices but a leader must have the ability to make good decisions quickly and effectively. Often times, those closest to you may not agree with your choice but being decisive may be the difference between life and death.3. Problem Solving: A leader must have the ability to solve a problem, whether that problem is in the conception of ideas, in the operation of the organization or even with individuals. They must try to see clearly and be objective. When problems are ignored or not resolve they can grow and become even more dangerous later on.4. Compassion: A good leader not only cares about achieving their vision but is also empathetic to the needs and concerns of others, especially of those that follow you. A simple compassionate act can motivate even the most disheartened follower to continue on or persuade the hardest enemy to see differently. Leaders must show that they care!As you may see, these few characteristics are not actually about the leader but how the leader related to others in their role as leader. Successful people position themselves well; successful leaders position others well. Not through favouritism or elitism but through vision. Because the greatest legacy of any leadership is producing more leaders not devoted followers.END.Damian WilsonTCI Patriot National Leadership Conference announced, Youth to get training Recommended for you Natl Leadership Conference begins today; Registration still on Facebook Twitter Google+LinkedInPinterestWhatsApp Vote Your Voice says they did not collect any forms during drive
Mats Seuntjens couldn’t believe his eyes as his brilliant chip bounced away from the goal just as he begun to celebrateThe Dutch midfielder chipped the ball from the edge of the penalty area on the right side to potentially hand AZ Alkmaar an unlikely goal in their KNVB Cup tie with PEC Zwolle.The ball went past the helpless Zwolle goalkeeper and appeared to be heading straight into the goal only for it to then take a backspin off the goal line.This left a flabbergasted Seuntjens crutching his hips wondering what happened.“Unbelievable. Unfortunately, there was just too much effect on the ball,” said Seuntjens afterwards, via talkSPORT.Europa League draw groups K and L George Patchias – August 30, 2019 Europa League groups K and L were kind to Wolves and United, weren’t they?UEFA.com confirmed that Europa League group K consists of, Besiktas, Braga,…“Really too bad, because it was a great ball, even if I say so myself. ”Although AZ did still win 5-0 anyway and progressed through to the quarter-finals of the KNVB Cup.Here’s Ralf Seuntjes of AZ scoring a delightful lob over the… hang on, nope.pic.twitter.com/T21KEw866O— GoalScorer Challenge (@GoalscorerC) December 19, 2018
The Vancouver City Council will take a more prominent role in the state-level permitting process of a proposal for an $110 million oil terminal at the Port of Vancouver.How much more prominent wasn’t explored Monday during a council update on the proposal by Tesoro Corp. and Savage Companies to build the Northwest’s largest oil-by-rail facility.Councilors indicated they will file a motion to intervene, which would give the city standing to make arguments directly to the state Energy Facility Site Evaluation Council (EFSEC), introduce evidence, cross-examine witnesses and appeal the decision.They stopped short of either expressing support or disapproval, however.As with the concerns submitted to EFSEC last year as part of a scoping process to determine what should be included in an environmental review, councilors remained neutral.The closest anyone got to stating an opinion about the proposed oil terminal was when Councilor Bart Hansen said he’s not particularly pleased with what he’s seen of the proposal.
WILMINGTON, MA – The Catholic Community of Wilmington and South Tewksbury’s Charities Committee is conducting a Thanksgiving Food Drive to help families in need within the St. Thomas and St. Dorothy’s parishes.Donations can be left inside the entrances of both St. Thomas and St. Dorothy’s on Saturday, November 10 and Sunday, November 11.Requested, non-perishable food items include:GravyInstant PotatoCranberry SauceStuffingRiceCanned Veggies (corn, green beans, yams, peas, carrots)Chicken & Turkey Stock BrothBread & Roll MixCanned Fruit & ApplesauceCoffee, Tea & Hot CocoaPancake Max & SyrupCake Mix & FrostingPie Crust Mix & Pie FillingBrownie MixNuts/ChocolatesChip/Dip/SalsaGrocery Store Gift Cards (in any denomination)If you are interested in donating a complete Dinner Basket for a family, the estimated cost is approximately $50. Monetary donations or gift cards can be brought to the Parish Office, marked “Thanksgiving,” or placed in the offertory collection.If you would like to have your donation picked up or have questions, please contact Rose Jackson at firstname.lastname@example.org or 978-658-9915.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWILMINGTON GIVES: St. Thomas & St. Dorothy’s Holding Thanksgiving Food Drive This WeekendIn “Community”St. Thomas & St. Dorothy’s Holding Thanksgiving Food Drive On November 11-12In “Community”St. Thomas & St. Dorothy’s Holding Thanksgiving Food Drive This WeekendIn “Community”
TikTok, which allows users to create and share short videos with special effects, has become hugely popular in India.ReutersGoogle has blocked access to the hugely popular video app TikTok in India to comply with a state court’s directive to prohibit its downloads, a person with direct knowledge of the matter told Reuters on Tuesday.The move comes hours after a court in southern Tamil Nadu state refused a request by China’s Bytedance Technology to suspend a ban on its TikTok app, putting its future in one of its key markets in doubt.The state court had on April 3 asked the federal government to ban TikTok, saying it encouraged pornography and made child users vulnerable to sexual predators. Its ruling came after an individual launched public interest litigation calling for a ban.The government had sent a letter to Apple and Google to abide by the state court’s order, according to an IT ministry official.The app was still available on Apple’s platforms late on Tuesday but was no longer available on Google’s Play store in India.Google said in a statement it does not comment on individual apps but adheres to local laws. Apple did not respond to requests for comment, while TikTok did not immediately respond to a request for comment on Google’s move.TikTok, which allows users to create and share short videos with special effects, has become hugely popular in India but has been criticized by some politicians who say its content is inappropriate.It had been downloaded more than 240 million times in India, app analytics firm Sensor Tower said in February. More than 30 million users in India installed it in January 2019, 12 times more than in the same month last year.Jokes, clips and footage related to India’s thriving movie industry dominate the app’s platform, along with memes and videos in which youngsters, some scantily clad, lip-sync and dance to popular music.Bytedance challenged the state court’s ban order in India’s Supreme Court last week, saying it went against freedom of speech rights in India.The top court had referred the case back to the state court, where a judge on Tuesday rejected Bytedance’s request to put the ban order on hold, K. Neelamegam, a lawyer arguing against Bytedance in the case, said.TikTok earlier said in a statement that it had faith in the Indian judicial system and was optimistic about an outcome that would be well received by millions of its users. It did not comment further on the judge’s decision.The company, however, welcomed the decision to appoint a senior lawyer to assist the court in upcoming proceedings.The state court has requested written submissions from Bytedance in the case and has scheduled its next hearing for April 24.Salman Waris, a technology lawyer at TechLegis Advocates & Solicitors, said the legal action against Bytedance could set a precedent of Indian courts intervening to regulate content on social media and other digital platforms.In its Supreme Court filing, Bytedance argued that a very minuscule proportion of TikTok content was considered inappropriate or obscene.The company employs more than 250 people in India and had plans for more investment as it expands the business, it said.
Three employees of a call centre run by Wipro for London-based telecom service provider TalkTalk have been arrested in India for alleged breach of security.The arrests in Kolkata earlier this month were made after TalkTalk detected the alleged breach while conducting a data security review and informed the police, reported PTI.While confirming the arrests, TalkTalk clarified they were not related to a hacking detected last October when personal information of its customers were “compromised”. “Following the October 2015 cyber-attack, we have been conducting a forensic review to ensure that all aspects of our security are as robust as possible â€” including that of our suppliers. Acting on information supplied by TalkTalk, the local police have arrested three individuals who have breached our policies and the terms of our contract with Wipro. We are also reviewing our relationship with Wipro,” PTI quoted TalkTalk as saying in a statement.Wipro has said it is “working closely” in the investigation and will “extend its full cooperation” to the authorities probing the allegations.”Wipro is committed to maintaining the integrity and confidentiality of all customer data, and has a zero-tolerance policy on security breaches,” the Bengaluru-based company said in a statement.”Wipro is working closely with the customer in the investigation and will continue to extend its full cooperation to the investigating authorities,” Wipro was quoted by PTI as saying.
Instagrams New Update That Sparked Outrage Was Just A Test Close Instagram is working on many features and changes that are going to change a lot of things for its users and influencers. While the news of Instagram hiding like counts on the platform has brought mixed feelings, it’s not the only big change that is going to embrace the social media app. If you haven’t updated your Instagram app, a new version has arrived with a few changes that you might or might not like.Instagram for Android received a new update and with it came a major redesign. The change is mainly for the profile page of Instagram accounts, where things have been shuffled a bit. Users are familiar with the years-long design where the profile photo appears on the top left with the user’s name and bio beneath. The counter for Posts, Followers, Following alongside “Edit Profile” option is alongside the profile photo.The profile design has been unchanged for a long time, making it quite familiar and easy to use. But Instagram decided to bring a new change to the way profiles look and users might need some time to adjust to it. Instagram new update changes profilesIBTimes India/Sami KhanThe new design for Instagram profiles now show the handle right on top and the name user has chosen to be displayed just below it in larger font size. This way, the name of the account holder is highlighted. The account bio, if the user has added, appears below the name in a smaller font, followed by the number of followers and the accounts that the user follows. The number of Posts is no longer shown on the profile.The profile photo appears on the top right corner, just below the settings menu and story archives. There’s a bigger Edit Profile button, which also separates the profile information from the content posted on the account. Users’ Stories will appear below the edit button followed by photos and videos users have posted on the account.Check out the difference below: Instagram new update changes profilesIBTimes India/Sami KhanInstagram is clearly putting the focus on the content here and the information, which would otherwise miss the visitor’s attention. The change is as big as the upcoming features like new Stories camera UI with Create Mode, Shopping from Creators option, Donation Stickers and hiding the precious likes, which is the bread and butter for a lot of influencers out there.Hiding the likes on photos doesn’t take away much from genuine influencers as they can still share statistics about the post’s reach. This will help businesses connect with the right influencers. IBTimes VideoRelated VideosMore videos Play VideoPauseMute0:02/1:10Loaded: 0%0:02Progress: 0%Stream TypeLIVE-1:08?Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedSubtitlessubtitles settings, opens subtitles settings dialogsubtitles off, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window. COPY LINKAD Loading …
People chant slogans and hold signs to condemn the rape and killing of 7-year-old girl Zainab Ansari in Kasur, during a protest in Peshawar, Pakistan. Photo: ReutersTwo civilians were killed when officers fired live rounds to disburse crowds that attacked a police station in Pakistan on Wednesday in a protest over the rape and murder of a 7-year-old girl.Police recovered the body of Zainab Ansari on Tuesday from a garbage dumpster in the town of Kasur in eastern Pakistan, four days after she was reported missing.It was the twelfth incident of a girl being adducted, raped, and killed in the past year in Kasur district, police say. Residents have been furious at the authorities for what they see as a failure to investigate such cases.The spokesman for Pakistan’s Punjab province, Malik Muhammad Ahmad Khan, told Reuters that protesters turned violent and attacked a local police office.”They started throwing stones at the office and some of armed protesters shot bullets at police. In order to stop them, police resorted to aerial firing,” Khan said, adding that two people were killed and one wounded as a result.Locals said police responded with undue force.”A peaceful protest was taking place, some students threw stones and police responded by firing at the crowd,” Saleem ur Rehman, a resident who was at the protest, told Reuters. “The law and order situation here is really bad and there have been many such incidents. That is what the protest was about.”Ansari’s parents, who were not in the country when their daughter was kidnapped, returned on Wednesday.”I want justice! I want justice!” Zainab’s mother cried, surrounded by reporters at the international airport in the capital Islamabad.Ansari’s case has attracted the attention of the country’s civilian and military leadership, with Punjab Chief Minister Shahbaz Sharif calling for immediate action.Police in Kasur deny they have been lax in investigating child abductions in the town. Regional police officer Zulfiqar Hameed told Reuters that four kidnappers had been arrested and another killed during an arrest attempt.”Investigations reveal that in each case a paedophile kidnaps little girls, rapes them and kills them,” he said.The case of Ansari would soon be solved, he said: “We have got CCTV footage that shows a young man taking her along. We will catch him very soon,” he said, adding that 95 DNA samples had been taken from suspects.A number of police officials have been transferred out of the region for failing to investigate complaints of missing children since 2015, when authorities uncovered what they called a paedophile ring linked to a prominent local family. At least two people have been convicted in the case, in which authorities say hundreds of children in the district were abused.
By The Associated PressMILAN (AP) — Italian brand Prada said it is forming a diversity council to “elevate voices of color within the company and fashion industry at large,” a move that follows accusations of racism in the luxury fashion world.Two Americans, artist Theaster Gates and film director Ava DuVernay, will chair the council, Prada said Wednesday. The group will work to develop “diverse talent” and create more opportunities for students of color, the luxury fashion house said.In this Nov. 18, 2018, file photo filmmaker Ava DuVernay addresses the audience during the 2018 Governors Awards at The Ray Dolby Ballroom in Los Angeles. (Photo by Chris Pizzello/Invision/AP, FIle)Gates said his work “amplifies the voices that have been absent from the broad cultural conversations,” and he was happy to work with Prada to help make the company more “reflective of the world today.”Prada apologized in December and immediately withdrew bag charms with exaggerated red lips. Critics said the charms recalled the Blackface caricatures that long propagated racist stereotypes in the United States.The fashion world controversy intensified after a similar misstep this month by Gucci. Another prominent African-American director, Spike Lee, said he would wear neither Prada nor Gucci until they included Black designers.“Prada is committed to cultivating, recruiting and retaining diverse talent to contribute to all departments of the company,” said Miuccia Prada, CEO and creative director. “In addition to amplifying voices of color within the industry, we will help ensure that the fashion world is reflective of the world in which we live.”She said the initiative would “help us grow not only as a company, but also as individuals.”Blackface caricatures popularized in 19th century minstrel shows also have attracted renewed attention in the United States after old photos emerged of White politicians wearing Blackface or condoning it.
By Associated PressHundreds of people marched to honor the memory of a 4-year-old Houston girl who was missing for several weeks before her remains were found last month in Arkansas.Family members of Maleah Davis as well as area residents walked through downtown Houston on Sunday.Hundreds gathered in downtown Houston on June 9 to honor the legacy of 4-year-old Maleah Davis, who was missing for weeks, before her remains were later found in Arkansas. (AP Photo)After the march, people gathered at City Hall. Craig Davis, Maleah’s father, spoke briefly, thanking the crowd for their support and saying the march meant so much to his family.The city of Houston declared Sunday as “Maleah Davis Day.” Later in the evening, officials lit up City Hall in pink lights, which was the girl’s favorite color.Derion Vence, the ex-fiance of Maleah’s mother, is jailed on a tampering with evidence charge in the case. Authorities say additional charges could be filed.
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: ArduSat-1 and ArduSat-X CubeSats launched into space (2013, August 8) retrieved 18 August 2019 from https://phys.org/news/2013-08-ardusat-ardusat-x-cubesats-space.html (Phys.org) —Japan Aerospace Exploration Agency (JAXA) has successfully launched an H-2B cargo rocket into space—a portion of which is bound for a rendezvous with the International Space Station. After it docks, two CubeSats—ArduSat-1 and ArduSat-X—held in its cargo module will be deployed into an orbit above the Earth. Talking humanoid robot launches on Japan rocket © 2013 Phys.org The two tiny cube-shaped satellites will be pulled from the same cargo module that holds Kirobo—a talking humanoid type robot designed to study whether astronauts might benefit from an electronic companion. The small satellites usher in a new low cost era in space technology—each will offer the possibility of non-professionals running real-time experiments aboard a real orbiting satellite.Both of the miniature satellites are loaded with technology, including cameras, ozone and CO2 sensors, a Geiger counter and temperature gauges. They also have an onboard computer running Arduino, an open-source platform that allows for controlling instruments aboard the craft. Arduino was chosen because it is an already established platform used by educational institutions and hobbyists alike.Both craft have a set list of objectives to fulfill before time runs out—both will plummet to the Earth at some point in time between three and seven months. Once its initial objectives have been fulfilled, the satellite will be made available to other projects run by customers on the ground. $125 will get a user three days worth of satellite time while $250 will get a whole week. Since each satellite is capable of running 16 experiments simultaneously, there will be plenty of opportunities for schools and other organizations to take advantage of this unique opportunity.Shortly after docking with the ISS, ArduSat-1 and ArduSat-X will be pulled from the cargo module by a robotic arm which will then release them into space. The two CubeSats were partly built in Australia and were also partly funded via a Kickstarter project. The aerospace company responsible for their creation is Nanosatisfi LLC—their stated goal is to “democratize access to space.” They deployment of the two CubeSats is just the beginning they have told reporters. They hope to send up hundreds or even thousands of tiny satellites allowing almost anyone with a desire to perform experiments in space, a platform for doing so. Explore further CAD Drawing of ArduSat. Credit: Peter Platzer / Wikipedia.
Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Single-molecule resolution of protein structure and interfacial dynamics on biomaterial surfaces, PNAS November 26, 2013 vol. 110 no. 48 19396-19401, doi:10.1073/pnas.1311761110 Moreover, Kaar continues, monitoring molecule-by-molecule structure changes in organophosphorus hydrolase had its own challenges related to eliminating mislabeled protein molecules – that is, molecules with other than one donor and one acceptor fluorophore – from analysis. “We met this challenge by creating and implementing filters during data analysis that separated signals from properly labeled and mislabeled species.”Kaar points out that using SM-FRET tracking had its own issue. For one, it required high-throughput tracking algorithms (developed by co-authors Kastantin and Schwartz) critical to monitor changes in FRET signals for large numbers of molecules, which in turn was essential to identifying protein structure changes accurately (that is, with high statistical confidence). He points out that SM-FRET also required prior knowledge of the crystal structure of OPH, which was needed to make the FRET signal indicative of quantitative changes in protein conformation.The study’s results suggest that surfaces may act as a source of unfolded (that is, aggregation-prone) protein back into solution – but validating this implication faces the challenge of identifying the conformation of protein molecules immediately before desorption from the surface. “The question of whether the unfolded proteins induced aggregation in solution after desorption remains to be fully understood,” Kaar explains. “Fully understanding if this is actually the case requires further analysis of protein in solution in the presence of the surface.”The team leveraged two key innovations to address these research challenges – the implementation of site-specific labeling methods, and high-throughput tracking algorithms with SM-FRET. “Combining these methods enabled the decoupling of surface-induced conformational changes from protein adsorption and desorption events,” Kaar notes. “By decoupling such phenomenon, this approach allowed us to overcome the limitations of conventional surface characterization methods.”The research also shows that SM-FRET permits a unique level of understanding of the ways in which surface chemistry influences molecular conformation and, in turn, function. “By observing molecular-level changes in protein structure in isolation from competing surface dynamics, it’s easier to make a direct connection between surface chemistry and conformation,” Kaar points out. “Therefore, it is more straightforward to see the effects of surface chemistry and can lead to new ideas for how to improve chemistry for a given application.Another important finding is that the new method will enable the creation of surfaces and modifications with improved biocompatibility by uncovering the connection between surface properties and protein unfolding. “This connection is critical to inspiring and developing surfaces and modifications that meld with the biological world,” Kaar explains. “For example, with this understanding, we can begin to design surfaces that promote protein folding and therefore favorable responses from cells present in the surrounding milieu. In this example, the folded state of the protein may display certain biological signals to cells that thwart unwanted inflammatory or harmful reactions while instructing cells to respond in ways that may facilitate proliferation, differentiation or even wound healing in vivo.”Kaar tells Phys.org that future experiments are aimed at determining if the observed effects of fused silica on organophosphorus hydrolase are general or specific to this combination of surface and protein. “We plan to address this question by probing how fused silica and surfaces with other properties impact the folding of other proteins. We’re also interested in expanding our methods to understand how surface effects on conformation impact the binding of a third protein species. Understanding this impact is critical to, for example, enumerating how cells respond to biological cues on surfaces in physiological environments.” Other innovations that the researchers may develop, Kaar adds, include more sophisticated labeling to minimize SM-FRET protein mislabeling on surfaces, as well as labeling and detection schemes to enable multiple molecular events, including unfolding and binding, to be monitored simultaneously.”Given that the interaction of proteins and surfaces are relevant in virtually all areas of biotechnology,” Kaar notes, “many other areas of research – for example, tissue engineering and regenerative medicine, biosensing, biocatalysis, and pharmaceutical protein formulation – may benefit from exploiting our approach.” (Phys.org) —Proteins accomplish something rather amazing: A protein can have many functions, with a given function being determined by the way they fold into a specific three-dimensional geometry, or conformations. Moreover, the structural transitions form one conformation to another is reversible. However, while these dynamics affect protein conformation and therefore function, and so are critical to a wide range of areas, methods for understanding how proteins behave near surfaces, which is complicated by protein and surface heterogeneities, has remained elusive. Recently, however, scientists at University of Colorado utilized a method known as Single-Molecule Förster Resonance Energy Transfer (SM-FRET) tracking to monitor dynamic changes in protein structure and interfacial behavior on surfaces by single-molecule Förster resonance energy transfer, allowing them to explicate changes in protein structure at the single-molecule level. (SM-FRET describes energy transfer between two chromophores – molecular components that determine its color.) In addition, the researchers state that their approach is suitable for studying virtually any protein, thereby providing a framework for developing surfaces and surface modifications with improved biocompatibility. Journal information: Proceedings of the National Academy of Sciences © 2013 Phys.org. All rights reserved. Citation: Two for the price of one: Single-molecule microscopy simultaneously monitors protein structure and function (2013, December 4) retrieved 18 August 2019 from https://phys.org/news/2013-12-price-single-molecule-microscopy-simultaneously-protein.html Protein surfaces defects act as drug targets Structure of OPH showing the position of site-specific donor and acceptor labeling. OPH is a homodimer (C2 symmetry) that consists of two (α/β)8 monomers. The position K175, which was replaced with AzF in monomers A and B of OPH, is highlighted (yellow). Credit: Copyright © PNAS, doi:10.1073/pnas.1311761110 Prof. Joel L. Kaar discussed the paper he and his co-authors, Dr. Sean Yu McLoughlin, Prof. Mark Kastantin and Prof. Daniel K. Schwartz, recently published in Proceedings of the National Academy of Sciences. “The primary challenges in devising our approach to characterizing changes in protein structure were implementing a site-specific labeling method, which enabled single-molecule resolution, as well as a method to only image molecules at the solution-surface interface,” Kaar tells Phys.org. The scientists overcame the former challenge by incorporating unnatural amino acids – that is, those not among the 20 so-called standard amino acids – with unique functional groups for labeling with fluorophores (chemical compounds that can re-emit light upon light excitation); the latter, by using total internal reflection fluorescence microscopy, which only excites molecules in the near-surface environment, thereby minimizing the background fluorescence of molecules free in solution. “Although site-specific labeling methods have been used to monitor changes in protein conformation mainly in bulk solution, such techniques have not previously been exploited to study freely diffusible protein molecules at interfaces,” Kaar adds. As such, the researchers are the first to apply site-specific labeling methods to study protein-surface interactions,”The major challenge associated with incorporating unnatural amino acids for labeling was related to the optimization of protein expression,” Kaar continues. Specifically, he explains, the expression of the enzyme organophosphorus hydrolase (OPH) – which is notoriously difficult to make in large quantities due to inclusion body formation – with the unnatural amino acid p-azido-L-Phe (AzF) had to be optimized to efficiently incorporate p-azido-L-Phe. (Inclusion body formation refers to the intracellular aggregation of partially folded expressed proteins,) “This process required modification of expression conditions,” he adds, “in which bacteria with modified genetic machinery were grown to enable production of soluble enzyme for single-molecule experiments.”
Punter found hiding in bushes Get the biggest Daily stories by emailSubscribeSee our privacy noticeThank you for subscribingSee our privacy noticeCould not subscribe, try again laterInvalid EmailDrivers are being warned to expect long delays on the M6 as a camper van fire blows smoke across the motorway. Emergency services were called to the scene on the northbound carriageway between junction 14, for Stafford North, and 15, for Stoke-on-Trent, shortly before 2.45pm. Staffordshire Fire and Rescue Service confirmed they were attending the incident not far from junction 15. Traffic monitoring company Inrix reports all three lanes are being temporarily held as the fire service arrive at the scene. An Inrix spokesman said: “All traffic is being temporarily held and there is stationary traffic due to vehicle fire and smoke blowing across the road on M6 Northbound from J14 A34 (Stafford North) to J15 A500 D Road (Stoke-On-Trent). In the roadworks area. Read MorePolice name man arrested and charged with attempted rape of young girl “All traffic was held at around 2.45pm. Currently we are unable to tell what type of vehicle is on fire, but the fire service is in attendence.” Highways England is also aware of the incident. Read MoreTop stories on StokeonTrentLive Police search for missing woman Dad slams ‘disgusting’ hospital window Driver named following fatal collision Follow StokeonTrentLive Download our app – You can download our free app for iPhone and iPad from Apple’s App Store , or get the Android version from Google Play . Follow StokeonTrentLive on Facebook – Like our Facebook page to get the latest news in your feed and join in the lively discussions in the comments. Click here to give it a like! Follow us on Twitter – For breaking news and the latest stories, click here to follow SOTLive on Twitter . Follow us on Instagram – Featuring pictures past and present from across Stoke-on-Trent, North Staffordshire & South Cheshire – and if you tag us in your posts, we could repost your picture on our page! We also put the latest news in our Instagram Stories. Click here to follow StokeonTrentLive on Instagram .
Related posts:Costa Rica should expect 4.3 percent GDP growth, World Bank says López, Guatemala’s 1st billionaire, beating Slim with Tigo Mobile Fitch Ratings downgrades Costa Rica outlook As budget battles loom, Biden asks US Congress to approve aid for Central America PANAMA CITY – The economies of Central America will grow an average of 3.5 percent this year, half a point more than that estimated for Latin America and the Caribbean, according to the Inter-American Development Bank (IDB).“The estimated economic growth for this year in Central America is 3.5 percent,” said Gina Montiel, manager for the IDB in the Dominican Republic and the region, who added that the estimate for Latin America is 3 percent.Montiel offered the information during the 26th Central American and Dominican Republic Governors Meeting, which brings together finance ministers and other economic authorities from across the region.The financial corporation believes that Central America and the Dominican Republic should make structural changes that allow it to improve competitivity while considering the drop in the price of basic goods that the region exports.The IDB also recommended taking advantage of the improving U.S. economy, the principal market for Central American exports.The continued recovery of developed economies, especially the United States, will push global growth from 2.4 percent in 2013 to 3.2 percent in 2014, according to the World Bank.“The principal challenge for the region is taking advantage of the North American economy,” said IDB President Luis Alberto Moreno. Facebook Comments
Princess Cruises’ Enchanted PrincessPrincess Cruises announces biggest European season with newest ship Enchanted PrincessPrincess Cruises has announced 2020 will be its biggest European season ever, and is set to see its fifth Royal-class ship Enchanted Princess debut in June 2020 with a series of Mediterranean voyages.As part of its maiden season, Enchanted Princess will sail from Barcelona, Athens and Rome, offering a variety of cruises from seven to 12-nights.“Europe is our top long-haul fly-cruise destination for Australian guests – and, in 2020 we’re pleased to announce we have three of Princes Cruises’ newest ships Enchanted, Sky and Regal based in the region,” says Senior Vice President Princess Cruises Asia Pacific, Stuart Allison.“Australians love discovering Europe by sea, with the continent offering a rich mix of history and culture that appeals to our guests.”In addition, the 2,200-guest Island Princess will spend August to October sailing around Northern Europe while the 3,080 Crown Princess will cruise both Northern and Southern Europe.Both ships including a series of new voyages:An eight-day Norwegian Fjords voyage on Crown Princess to Bergen, Aalesund, Olden/Nordfjord, Hellesylt Geiranger and StavangerA 13-day summer holiday cruise in August on Crown Princess to Barcelona, Marseille, Florence/Pisa, Rome, Sardinia and Ceuta in Spanish MoroccoA 17-day Mediterranean voyage on Crown Princess to Lisbon, Santorini (Greece), Mykonos (Greece), Kusadasi (Turkey), Katakolon (Turkey) and Cartagena (Spain)A 12-day Northern Capitals cruise on Island Princess to cities including Hamburg (for Berlin), Copenhagen, Oslo, Amsterdam, Brussels and Paris (via Le Havre)A 14-day Scandinavia & Russia Collection cruise on Island Princess to Bornholm (Denmark), Stockholm, Helsinki (Finland), St. Petersburg, Tallinn (Estonia), Riga (Latvia), Visby (Sweden), Helsingborg (Sweden) and Copenhagen. The calls to Stockholm and St Petersburg are both overnight visitsTwo 12-day Northern Lights cruises on Island Princess via the Norwegian destinations of Aalesund, Tromso, Alta (overnight) and StavangerMeanwhile the 3,660-guest Sky Princess, which launches in 2019, will spend its first European spring and summer season sailing Scandinavia and Russia roundtrip from Copenhagen. From April to September Sky Princess will take in the likes of Stockholm, Oslo, Tallinn, Helsinki, Berlin and an overnight stay in St Petersburg.Closer to home, the cruise line announced 2020 will be its longest Japan season yet – with Diamond Princess set to offer 44 itineraries, travelling to 41 destinations across Japan, Taiwan, South Korea and Russia.The sailings will explore Japan’s natural beauty and rich culture, featuring 10 UNESCO World Heritage Sites, seven local festivals and five spring flower voyages among the highlights.“Our 2020 Japan journeys give Australian travellers more choice than ever before. And, with ten of our ports offering More Ashore, we’re confident our guests will have the opportunity to experience all that Japan has to offer – from the shining lights of Shinjuku to the charm of cherry blossom season,” says Allison.The announcements form part of Princess Cruises’ 2020 programme, which includes sailings across Europe as well as Asia, the Caribbean, Alaska and Canada & New England.Further afield, highlights include:65 Japan voyages setting sail from either Tokyo or Kobe on the 2,670-guest Diamond Princess28 summer Caribbean cruises from Fort Lauderdale with seven, 14 and 21-night optionsOver 130 Alaska sailings across eight ships, with departures from Los Angeles, Seattle, San Francisco, Whittier and Vancouver16 Canada & New England sailings on Sky Princess or Caribbean Princess, which depart from Fort Lauderdale, New York or QuebecFares for 14-night cruise onboard Enchanted Princess’ Western Mediterranean & Aegean Medley cruise from Barcelona to Athens departing 25 July 2020 start from $4,219 per person twin share.**Subject to availability, conditions apply.Source = Princess Cruises
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