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Mavericks stop 4-game slide with win against Bucks

first_imgKidd said his team should have been ready for the 3-point barrage.“Coming into the game we had talked about how they are second in the league in attempts,” Kidd said. “They just haven’t made them. But tonight they made up for all those misses.”Milwaukee went 6 of 25 from 3-point range.TERRY RETURNSJason Terry played the final couple minutes for Milwaukee and got a standing ovation from the crowd. The 40-year-old Terry played for Dallas from 2004 to 2012 and helped the Mavs win the NBA title in 2011.Terry scored on his only field-goal attempt, leading to a large roar from the crowd.“I knew he was gonna score,” Mavericks coach Rick Carlisle said. “I was gonna clap, I wasn’t sure how appropriate that was. You know how I feel about him, that’s one of the reasons we’re all wearing rings here.”TIP-INSBucks: C John Henson went 3 for 10 at the free-throw line. … Kidd had two stints in Dallas as a player and averaged 10.5 points, 5.5 rebounds, and 8.4 assists in 500 career games with the Mavericks. … The Bucks host the Mavericks on Dec. 8.Mavericks: C Nerlens Noel only played three minutes. Noel played six minutes in Friday night’s 111-87 loss to Minnesota and has been replaced in the rotation by Salah Mejri. … Dallas still leads the NBA with 14 losses this season. View comments Milwaukee had won four in a row. Giannis Antetokounmpo had 24 points and 17 rebounds for the Bucks (8-7), and Khris Middleton added 23 points.It was Milwaukee’s first loss since it acquired Eric Bledsoe in a trade with the Phoenix Suns on Nov. 7.“I think the ball was just stuck,” Bucks coach Jason Kidd said. “The ball got sticky and we were afraid to let go of it to a teammate.”The Mavericks never trailed after Matthews’ 3-pointer made it 22-20 with 3:07 left in the first quarter. Dallas went 19 for 38 from beyond the arc, including a shot clock-beating 3 from near midcourt by Barea that made it 88-64 in the fourth quarter.“I had to shoot that one,” Barea said. “You don’t see a lot of those.”ADVERTISEMENT Japan ex-PM Nakasone who boosted ties with US dies at 101 UP NEXTBucks: Host the Washington Wizards on Monday.Mavericks: Host the Boston Celtics on Monday. LATEST STORIES Kammuri turning to super typhoon less likely but possible — Pagasa Typhoon Kammuri accelerates, gains strength en route to PH Dallas Mavericks’ Dirk Nowitzki (41), of Germany, shouts at an official calling for a foul after attempting a shot in the first half of an NBA basketball game against the Milwaukee Bucks, Saturday, Nov. 18, 2017, in Dallas. (AP Photo/Tony Gutierrez)DALLAS — The Dallas Mavericks’ first win in a couple weeks was quite a relief for Wesley Matthews and company.Matthews scored a season-high 22 points, and the Mavericks stopped a four-game slide with a 111-79 victory over the Milwaukee Bucks on Saturday night.ADVERTISEMENT CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Kris Aquino ‘pretty chill about becoming irrelevant’center_img MOST READ Stronger peso trims PH debt value to P7.9 trillion “It rejuvenates you,” Matthews said. “Everybody feels good. Aches don’t hurt as much, you just feel better about everything you’ve done. You don’t need moral victories, you’ve got the real one and you can actually see everything we’re trying to bring together.”Matthews also had eight assists while helping Dallas (3-14) to its first win since Nov. 7 at Washington. He had six of the Mavericks’ franchise record-tying 19 3-pointers.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout“We were playing basketball, and one of the hardest things to guard is random movement,” he said. “That’s when I’m at my best, when we’re just playing and stay in a rhythm.”J.J. Barea had 20 points for the Mavericks, and Harrison Barnes finished with 18. Yogi Ferrell had 16 points and Dwight Powell grabbed 13 rebounds. Brace for potentially devastating typhoon approaching PH – NDRRMC Harden scores 29 to lead Rockets past Grizzlies Trending Articles PLAY LIST 00:50Trending Articles02:29Giannis Antetokounmpo powers Bucks in bounce back win over Celtics00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Read Next Don’t miss out on the latest news and information. QC cops nab robbery gang leader, cohortlast_img read more

SEA Games: Suarez, two Filipino pugs enter semis; Paalam out

first_imgLacson: SEA Games fund put in foundation like ‘Napoles case’ Robredo should’ve resigned as drug czar after lack of trust issue – Panelo Fil-Briton Felix John Nobel Tupas finished the card with a dominant debut for the Philippines team in 81kg, banging Cambodian Felix Merlin Martinez via unanimous decision.READ: ‘Solid’ PH boxing team capable of taking home golds But the victories were tinged by the questionable defeat of Carlo Paalam to Malaysian Muhamad Fuad Redzuan in the 49kg.Paalam, one of the most promising boxers in the country at only 19 years old, was clearly on top of everything against the fighter who had earlier in his career lost to Filipinos Rogen Ladon and Elmer Pamisa.But Redzuan kept Paalam busy by dragging him down at least four times throughout the match.ADVERTISEMENT LATEST STORIES PH men’s volley team drops SEA Games opener to Vietnam Celebrity chef Gary Rhodes dies at 59 with wife by his side “I told myself that I need to win the favor of the crowd,” said Suarez in Filipino who unloaded his power punches that put Azmi on all fours. The Malaysian, though, made the count.READ: PH boxers make rousing 2017 SEA Games debutsFEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingMario Fernandez also advanced after a masterful unanimous decision win over Tran Phu Masuk of Vietnam in the 56kg.Fernandez, the defending champion in bantamweight division, controlled the match with his 1-2 combinations. READ: PH in for tough gold hunt in SEA Games; Athletics, boxing bright spotsThe Malaysian also threw haymakers coming from out of nowhere and landing very few.That decision shocked the Philippine team here drawing criticism as the Malaysian Sports Minister Brig. Gen. Khairy Jamaluddin Abu Bakar was in the sidelines.Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. Trending Articles PLAY LIST 00:50Trending Articles02:49World-class track facilities installed at NCC for SEA Games03:07PH billiards team upbeat about gold medal chances in SEA Games05:25PH boxing team determined to deliver gold medals for PH03:04Filipino athletes share their expectations for 2019 SEA Games00:45Onyok Velasco see bright future for PH boxing in Olympics02:25PH women’s volleyball team motivated to deliver in front of hometown crowd01:27Filipino athletes get grand send-off ahead of SEA Games00:36Manny Pacquiao part of 2019 SEA Games opening ceremonycenter_img Charly Suarez of the Philippines dominates Khir Akyazlan Bin Azmi of Malaysia in the quarterfinals of the light welterweight class men’s boxing competition of the 29th Southeast Asian Games at the MITEC Hall 8 in Kuala Lumpur. Suarez prevailed by unanimous decision. CONTRIBUTED PHOTO/SEA GAMES POOLKUALA LUMPUR — Two-time champion Charly Suarez battered Malaysia foe to score a convincing decision win and lead two other Filipino boxers to the Southeast Asian Games semifinals at MITEC Hall 8.Suarez slammed left and right upper cuts to the solar plexus of Khir Akyazlan Azmi in the third to win the 64kg quarterfinal match before a band of uniformed, boisterous crowd trying to distract the Filipino.ADVERTISEMENT MOST READ Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Pagasa: Storm intensifies as it nears PAR NATO’s aging eye in the sky to get a last overhaul Hotel says PH coach apologized for ‘kikiam for breakfast’ claim Trump signs bills in support of Hong Kong protesters View commentslast_img read more

Lovett Looking Forward To Coaching Role

first_imgNine debutants will take to the field for Australia at an Open level for the Mixed side in the Trans Tasman Test Series against New Zealand which starts tonight at Mudgee’s Glen Willow Regional Sporting Complex. Despite only six players still in the side following Australia’s 2011 World Cup final defeat over New Zealand, Lovett is confident his team has what it takes to continue Australia’s recent strong record over the Kiwis in the Mixed division. “Most of them are coming out of our Youth program and our Youth program has been quite strong since it was rebuilt after the 2005 Youth World Cup that we lost.”“They are new to Open’s but they’ve played international Touch before and they’ve come from some very good programs in their regional level and even their club based stuff. It’s actually quite a very good balance for me, there are some young players that are coming through, probably the one that is really a debutant is Michael Law. He’s a bit of an excitement machine, he’s super fast, he’s very agile, he reads the game well. He’s going to be a player to watch once he finds his feet at that level,” Lovett said. Lovett started his coaching career close to 20 years ago and in recent times has coached the Australian 20’s Boys at the 2009 Youth Trans Tasman Series as well as being the Australian Women’s Open assistant coach for the 2009 and 2010 Trans Tasman events as well as the 2011 World Cup. Lovett says that it’s been a long pathway to get to where he has, but he can’t wait to take on the Kiwis from Thursday.“I’m pretty excited. Coming from a developing state (Victoria) it’s a massive honour, things are a little bit different when you don’t come from Queensland or New South Wales so you have to get up a little earlier and work a little bit harder to keep up on your skills and the modern trends of the sport because it’s not directly at your back door.”“I think both the roles I’ve had in the past four years have been pretty important, with the Men’s 20’s and the Women’s Open because obviously it’s a crossover between both the girls and guys and stepping into Mixed is a new arena for me.”“The Open’s Women’s was good exposure to the pointy end of the sport, I got to work with some really good athletes in the Women’s program and some coaches who have been around for a long period of time as well in Kerry (Norman) and Dean (Russell). Both of them have helped hone and develop my skills as I’ve come through as well as my other mentors, so it’s been good.”Mixed specialist Manu Wakely is Lovett’s assistant coach for the series, with Wakely’s experience  in the Mixed arena both as a player and as a coach to be invaluable for the side. “I’m looking forward to working with Manu Wakely, he’s been a very successful Mixed coach and loves the detail, he pretty much lives and breathes Touch so it’s great to work with Manu and see his passion for the game.”Lovett says he will be looking to the more experienced players in his team, including co-captain’s Kylie Hilder and Rohit Prasad as well as Jamie Chan and Sarah Spacie, to guide the debutants along the way in the Series. Seeing some of his Australian 20’s Boys side from the 2009 Youth Trans Tasman progress into the Mixed Open side will also be an exciting prospect for Lovett, as well as unleashing a few new faces against New Zealand for the first time. “I’m looking forward to building a new team together with the senior playing group and fostering some of the development of some of the 20’s Boys I’ve brought through and exposing some of the new players we have like Peter Watkins, it will be exciting.”“We’ve got a strong side that has a lot of potential, but we’ve got to live up to our potential and deliver on the park. It’s their opportunity now to basically come to the international stage and try to deliver, and some of the young kids, seeing someone like Michael Law getting his opportunity being able to apply his trade at this level and how he takes that into the Youth programs going forward is exciting.”There are plenty of ways to keep in touch with the 2012 Trans Tasman Series, which will be held at Mudgee’s Glen Willow Regional Sporting Complex from Thursday, 26 April to Saturday, 28 April 2012, including in the following ways: Websites: www.austouch.com.au www.transtasman.mytouchfooty.com Facebook – www.facebook.com/touchfootballaustralia Twitter – www.twitter.com/touchfootyaus (be sure to use the hashtag #transtasman2012 in your tweets) YouTube – www.youtube.com/touchfootballauslast_img read more

20 days agoLeeds to cut short loan of Tottenham midfielder Jack Clarke

first_imgLeeds to cut short loan of Tottenham midfielder Jack Clarkeby Paul Vegas20 days agoSend to a friendShare the loveLeeds United are set to cut short the loan of Tottenham midfielder Jack Clarke.The Sun says the 18-year-old was loaned back to Elland Road after his £10million move to Spurs – but has not made a Championship appearance.And Marcelo Bielsa will have £10,000-a-week off the wage bill and a place in his squad when Clarke’s season-long deal is cut short.Bielsa is set to look for a loan signing to add competition for his first team for the second half of the season as the club battle for promotion. TagsTransfersLoan MarketAbout the authorPaul VegasShare the loveHave your saylast_img

Rep Brann votes to lower car insurance rates for Michigan drivers

first_img Categories: Brann News 09May Rep. Brann votes to lower car insurance rates for Michigan drivers State Rep. Tommy Brann today voted to approve a landmark plan to fix Michigan’s broken car insurance system and reduce rates for drivers all across the state.Brann said the plan offers drivers personal injury coverage options, reins in medical costs and fights fraud – reforms designed to end Michigan’s long-standing tenure as the state with the highest car insurance rates in the nation.Michigan is the only state to mandate unlimited lifetime health care coverage through car insurance. The plan approved today allows people currently using the coverage to keep it, and those who want it in the future to continue buying it – while providing more affordable options.“This is one of the issues I hear about most from people in our community,” Brann, of Wyoming, said after the vote. “I’m glad we were able to deliver a solution that lowers rates. I fought hard to keep the option to continue purchasing coverage that provides unlimited lifetime health care if they are injured in a car crash. This was not in the Senate bill and is important to me. This is the option my wife and I will be selecting – and I hope others will seriously consider it as well – but people deserve to weigh their options.”The plan:Guarantees lower personal injury protection rates for all Michigan drivers;Gives drivers a choice on car insurance policies;Stops potential price gouging on medical services for car accident victims;Combats fraudulent claims to help lower costs.The sweeping legislation now advances to the Senate for consideration.###last_img read more

Molecular signatures reveal why women are more likely to die from glioblastoma

first_imgIt is our expectation that this study could have an immediate impact on the care of patients with glioblastoma and further research. The findings indicate we should be stratifying male and female glioblastoma into risk groups and evaluating the effectiveness of treatment in a sex-specific manner.”Dr. Joshua Rubin, Co-senior Author Giovanni Cancemi | ShutterstockThe team identified distinct molecular signatures in tumors taken from men and women that helped to explain the disparity in treatment and survival rates.The study suggests that tailoring treatments based on the molecular subtype of men and women’s tumors may improve patient outcome. In a study of adults with glioblastoma, Dr. Joshua Rubin and colleagues found that women responded better to treatment than men.To investigate why, they used standard MRI scans to measure tumor growth velocity, enabling them to derive a value for how quickly tumors were growing.As reported in the journal Science Translational Medicine, the team then pulled patients’ MRI scan and survival data from a cancer research database and assessed tumor growth velocity every two months among 40 males and 23 females who received standard chemo-radiation therapy after they had undergone surgery.”The males did not respond as well, and we wanted to understand why, so we looked at the underlying genetics of patients’ tumors,” says Rubin.The researchers tapped into The Cancer Genome Atlas and applied advanced statistical algorithms that would distinguish male- or female-specific gene expression patterns from such patterns that were shared among the male and female patients.They then looked at sex-specific gene expression to find molecular subtypes that would correspond with the differences seen in male and female survival.Co-senior author Jingqin Luo says: “We observed tremendous genetic sex differences in the tumors of glioblastoma patients that correlated with survival.”The team found that tumors were clustered into five subtypes in males and five in females. Females with tumors from one cluster survived just over three years compared with just over one year among females with tumors from any of the other four clusters.Similarly, men with tumors from one cluster survived just over 18 months compared with just over one year among men who had tumors from the other four clusters.The team also identified genetic pathways that correlated with the longest survival and they were very different in males compared with females, says Rubin. For example, survival among males was partially dependent on the regulation of cell division, suggesting that medication to block the cell cycle may be more effective in men.Among women, survival was affected by regulation of invasiveness, indicating that targeting integrin signaling may be the most effective approach. This tells us it might be better to separate males and females and examine their sex-specific genetic signatures.”Joshua Rubin, Co-senior Authorcenter_img By Sally Robertson, B.Sc.Jan 2 2019Reviewed by Kate Anderton, B.Sc. (Editor)A study led by researchers at the Washington University School of Medicine has shed light on why more males than females develop and die from the deadly brain cancer, glioblastoma. SourceSex differences identified in deadly brain tumors.last_img read more

Innovative membrane offers a viable solution for periodontitis

first_img Source:http://newsroom.ucla.edu/releases/new-class-membranes-regenerate-tissue-bone-periodontitis Reviewed by James Ives, M.Psych. (Editor)Mar 22 2019Periodontitis affects nearly half of Americans ages 30 and older, and in its advanced stages, it could lead to early tooth loss or worse. Recent studies have shown that periodontitis could also increase risk of heart disease and Alzheimer’s disease.A team of UCLA researchers has developed methods that may lead to more effective and reliable therapy for periodontal disease — ones that promote gum tissue and bone regeneration with biological and mechanical features that can be adjusted based on treatment needs. The study is published online in ACS Nano.Periodontitis is a chronic, destructive disease that inflames the gums surrounding the tooth and eventually degrades the structure holding the tooth in place, forming infected pockets leading to bone and tooth loss. Current treatments include infection-fighting methods; application of molecules that promote tissue growth, also known as growth factors; and guided tissue regeneration, which is considered the optimal standard of care for the treatment of periodontitis.Guided tissue regeneration, in the case of periodontitis, involves the use of a membrane or thin film that is surgically placed between the inflamed gum and the tooth. Membranes, which come in non-biodegradable and biodegradable forms, are meant to act not only as barriers between the infection and the gums, but also as a delivery system for drugs, antibiotics and growth factors to the gum tissue.Unfortunately, results from guided tissue regeneration are inconsistent. Current membranes lack the ability to regenerate gum tissue directly and aren’t able to maintain their structure and stability when placed in the mouth. The membrane also can’t support prolonged drug delivery, which is necessary to help heal infected gum tissue. For non-biodegradable membranes, multiple surgeries are needed to remove the membrane after any drugs have been released — compromising the healing process.”Given the current disadvantages with guided tissue regeneration, we saw the need to develop a new class of membranes, which have tissue and bone regeneration properties along with a flexible coating that can adhere to a range of biological surfaces,” said Dr. Alireza Moshaverinia, lead author of the study and assistant professor of prosthodontics at the UCLA School of Dentistry. “We’ve also figured out a way to prolong the drug delivery timeline, which is key for effective wound healing.”The team started with an FDA-approved polymer — a large-scale synthetic molecule commonly used in biomedical applications. Because the polymer’s surface isn’t suitable for cell adhesion in periodontal treatment, the researchers introduced a polydopamine coating — a polymer that has excellent adhesive properties and can attach to surfaces in wet conditions. The other benefit of using such a coating is that it speeds up bone regeneration by promoting mineralization of hydroxyapatite, which is the mineral that makes up tooth enamel and bone.Related Stories’Text neck’ may be causing bone spurs in young peopleResearchers describe how prostate cancer cells develop ability to mimic osteoblastsEngineered stem cells offer new treatment for metastatic bone cancerAfter identifying an optimal combination for their new membrane, the researchers used electrospinning to bond the polymer with the polydopamine coating. Electrospinning is a production method that simultaneously spins two substances at a rapid speed with positive and negative charges, and fuses them together to create one substance. To improve their new membrane’s surface and structural characteristics, the researchers used metal mesh templates in conjunction with the electrospinning to create different patterns, or micro-patterning, similar to the surface of gauze or a waffle.”By creating a micro pattern on the surface of the membrane, we are now able to localize cell adhesion and to manipulate the membrane’s structure,” said co-lead author Paul Weiss, UC presidential chair and distinguished professor of chemistry and biochemistry, bioengineering, and materials science and engineering at UCLA. “We were able to mimic the complex structure of periodontal tissue and, when placed, our membrane complements the correct biological function on each side.”To test the safety and efficiency of their new membrane, the researchers injected rat models with gingival-derived human stem cells and human periodontal ligament stem cells. After eight weeks of evaluating the degradation of the membranes and the tissue’s response, they observed that the patterned, polydopamine-coated polymer membrane had higher levels of bone gain when compared to models with no membrane or a membrane with no coating.In order to suit a wide range of medical and dental applications, the researchers also figured out a way to adjust the speed at which their membranes degraded when inserted in their models. They did this by adding and subtracting different oxidative agents or using lighter polymer bases before going through the electrospinning process. The ability to turn the degradation rates up or down helped the researchers control the timing of the delivery of drugs to the desired areas.”We’ve determined that our membranes were able to slow down periodontal infection, promote bone and tissue regeneration, and stay in place long enough to prolong the delivery of useful drugs,” Moshaverinia said. “We see this application expanding beyond periodontitis treatment to other areas needing expedited wound healing and prolonged drug delivery therapeutics.”The researchers’ next steps are to evaluate whether their membranes can deliver cells with growth factors in the presence or absence of stem cells.last_img read more

CSUs Infectious Disease Research Center recognized as BioscienceMedical Manufacturer of the Year

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 30 2019Colorado State University’s Infectious Disease Research Center was recognized as the 2019 Bioscience/ Medical Manufacturer of the Year at the Colorado Manufacturing Awards on April 4 in Denver.The Colorado Manufacturing Awards are presented by CompanyWeek, which provides digital media reporting on the regional manufacturing economy, and Manufacturers Edge, the official representative of the Manufacturing Extension Partnership in Colorado.Center spurs collaborative research on human, animal diseasesThe Center was honored for its work to support the development and manufacturing of diagnostics, therapeutics and vaccine products on behalf of government, academic and private sector organizations.Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchOlympus launches next-generation X Line objectives for clinical, research applicationsTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTFinalists for the award included Cambrex and Osypka Medtec, both based in Longmont.The Infectious Disease Research Center offers university investigators, government scientists and industry representatives opportunities to collaboratively research the basic biology, biochemistry, molecular biology and epidemiology of bacteria and viruses that cause human and animal diseases.Ray Goodrich, director of the Infectious Disease Research Center, said he and his team were thrilled to be recognized for their efforts.”We work hard to integrate academic research and entrepreneurial companies at our world-class bio-manufacturing operation,” he added. Goodrich is also a professor in the Department of Microbiology, Immunology and Pathology, which is part of the College of Veterinary Medicine and Biomedical Sciences at CSU.Nomination highlights innovation, educationDan Powers, director of CO-LABS, a consortium which includes federal research laboratories, universities, state and local governments, economic development organizations, private businesses and nonprofit organizations, nominated the Infectious Disease Research Center for the award.In his nomination, Powers highlighted the work of the Rocky Mountain Regional Biocontainment Laboratory, Research Innovation Center, and BioMARC, which makes vaccines, therapeutics and diagnostics — all of which are based at the Infectious Disease Research Center on CSU’s Foothills campus. He also described the ways each of the facilities support innovation and education in the bioscience and medical realms throughout Colorado.”The Infectious Disease Research Center competed against some of the top manufacturers in Colorado,” said Alan Rudolph, vice president for research at CSU. “This is an exceptional award to win, especially for an academic institution.” Source:https://source.colostate.edu/infectious-disease-research-center-named-2019-bioscience-medical-manufacturer-of-the-year/last_img read more

New resistance mechanism that prevent formation of blood vessels

first_imgThe antibody of the study had the target Semaphorin 4D (Sema4D). Semaphorins are a large and diverse family of proteins from outside the cells, involved in cell signaling, and are essential for the development and maintenance of many organs and tissues. Some of them have implications for angiogenesis and cancer progression. Its name comes from the Greek semaphero, that means “bearer of signals”.Related StoriesMother calls for protein shake regulation after daughter diesSugary drinks linked to cancer finds studyTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSema4D is a protein that is expressed predominantly in the membrane of solid tumors, in cancers such as breast, prostate and colon cancer. This protein is also found in tumor-associated macrophages (TAMs), which are immune cells that play an important role in tumor invasion, tumor formation and in metastasis. The 4D Semaphorin is also related to the formation of blood vessels.Faced with this new situation, the researchers looked for which could be the differential factor from what was known to date, and they realized that there was a large presence of macrophages. They saw that, in the presence of the anti-Sema4D antibody, the macrophages secreted a molecule named SDF1, which causes the tumor cells to migrate more: they present more motility and more invasion.These tests were done in transgenic mice models and what was observed was an increased survival of animals in the short term. In the long term, however, an unwanted effect (metastasis) was generated, significantly worsening the condition of the mice.”Now that we know the new mechanism, we can begin to look for a way to inhibit it – for example, avoiding secretion of SDF1- and, in this way, to give an alternative to only have the positive effects of the antibody” explains Dr. Oriol Casanovas. He adds that “depending on each case, treatments could be carried out simultaneously with two drugs at the same time”.”What we propose is that the immune system is also taken into account when doing some therapies, because now we know that there may be the possibility of activating it with some drugs”, concludes Dr. Iratxe Zuazo. Source:IDIBELL-Bellvitge Biomedical Research InstituteJournal reference:Zuazo, I. et al. (2019) Anti-tumor effects of anti-Semaphorin 4D antibody unravel a novel pro-invasive mechanism of vascular targeting agents. Cancer Research. doi.org/10.1158/0008-5472.CAN-18-3436 In the formation of blood vessels (angiogenesis) it had been described that the conditions of low oxygen concentration (hypoxia) in the tumor were the cause of malignization of the tumor cells that became more aggressive and migrated, but our samples did not present hypoxia conditions and we still had this effect”.Dr Iratxe Zuazo, IDIBELL The mechanism does not activate the reduction of oxygen in the cells of the tumor, contrary to what common drugs, called anti-angiogenic, usually cause. In response to treatment, the immune cells of the tumor act as elements that make the tumor malignant. Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the ProCure Program of the Catalan Institute of Oncology (ICO) published today at Cancer Research a study describing a new mechanism in cancer that turns cells into malignant cells and contradicts what had been published so far about drug resistance that prevent the formation of blood vessels (anti-angiogenics). The research has been led by Dr. Oriol Casanovas, from the group of Tumor Angiogenesis of the IDIBELL, and the Dr Iratxe Zuazo has participated as one of the first authors.In the search for alternative factors to fight cancer, antibody development as a therapeutic route is one of them. Antibodies can have an anti-tumor effect, preventing tumors from developing properly. In this study, scientists observed that one of these antibodies led to similar effects to those known for traditional antiangiogenic medications. However, the initial response to treatment culminated in the appearance of long-term resistance and malignancy through a mechanism unknown to date. Reviewed by James Ives, M.Psych. (Editor)Jul 3 2019Researchers at IDIBELL-ICO describe a new resistance mechanism to therapies that prevent the formation of blood vesselslast_img read more

Nissan to cut hundreds of jobs at UK car plant source

Investment in UK automotive sector plunges by a third © 2018 AFP Explore further Japanese automaker Nissan will axe hundreds of staff at its car plant in northeastern England due to a sharp fall in diesel car sales, a source said Questioned about media reports of hundreds of job losses at Nissan’s factory in the coastal city of Sunderland, a source close to the matter confirmed the news but declined to give a timeframe.The news also comes as Britain’s car sector, which is largely foreign-owned, continues to face Brexit uncertainty on the horizon.The Sunderland plant—which builds the Juke, Leaf and Qashqai car models, many of which are diesel—employs 7,000 workers who produce some 500,000 vehicles per year.However, Nissan saw British sales slump 35 percent in the first quarter on an annual comparison.That mirrors a broader trend across the British automobile industry, with demand sliding on UK government plans to improve air quality.And diesel car sales are also struggling elsewhere in Europe.More and more consumers are choosing to ditch diesel cars in favour of automobiles that are regarded as more environmentally-friendly.The vast bulk of Sunderland-built Nissan cars are exported to elsewhere in Europe.Meanwhile, Friday’s news came as Nissan Motor Manufacturing UK (NMMUK) announced that it would implement a “short term” reduction in volumes at the sprawling Sunderland facility.”As previously communicated, we are transitioning to a new range of powertrains over the next year,” a company spokesman said.”As we make the operational changes required to support this, we will be managing a planned short-term reduction in powertrain supply and plant volumes at NMMUK in line with our 2018 business plan.”We are now discussing these operational changes with our employees.”However the spokesman declined to give any indication of job losses.The news comes after Jaguar Land Rover revealed one week ago that it will cut production and not renew the contracts of around 1,000 temporary workers at its Solihull plant in central England.The group, owned by India’s Tata Motors, blamed “continuing headwinds impacting the car industry”.Japan’s major automakers have meanwhile long expressed concerns about the impact of Brexit on their access to the European market.After receiving private guarantees from the British government, Carlos Ghosn, the head of Nissan, in October 2016 gave the green light to new investments in Sunderland.For its part, Japanese rival Toyota announced in March 2017 a multi-million-pound investment in a car assembly plant in central England, despite Brexit worries.Britain is scheduled to leave the European Union in March 2019 after a shock referendum that was held in June 2016. Citation: Nissan to cut hundreds of jobs at UK car plant: source (2018, April 20) retrieved 18 July 2019 from https://phys.org/news/2018-04-nissan-hundreds-jobs-uk-car.html Japanese automaker Nissan will axe hundreds of staff at its car plant in northeastern England due to a sharp fall in diesel car sales, a source told AFP on Friday. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Germanys CEBIT computer show scrapped after 32 years

first_img © 2018 The Associated Press. All rights reserved. Deutsche Messe AG said Wednesday that technology has become so ubiquitous that its presentation at other trade fairs has reduced demand for the 32-year-old CEBIT.The event began in 1986 and was once billed as the biggest computer show in the world, drawing around 800,000 visitors at its peak around the turn of the century.This year’s fair attracted 120,000 visitors. Most large technology companies prefer to launch new consumer products at CES in Las Vegas or the Mobile World Congress in Barcelona. Citation: Germany’s CEBIT computer show scrapped after 32 years (2018, November 28) retrieved 17 July 2019 from https://phys.org/news/2018-11-germany-cebit-scrapped-years.html Organizers say they are scrapping the annual CEBIT computer show in Germany, an event that has drawn tech enthusiasts to Hannover for more than three decades. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. World’s top tech fair pins hopes on Asia, social media Explore furtherlast_img read more

Fantastically Preserved Viking Boat Grave and Skeletons Unearthed in Sweden

first_img Photos: Vikings Accessorized with Tiny Metal Dragons Photos: 10th-Century Viking Tomb Unearthed in Denmark Fierce Fighters: 7 Secrets of Viking Seamen Archaeologists recently unearthed two Viking burial boats in Uppsala, Sweden — one of which was exceptionally preserved and held the remains of a dog, a man and a horse. The Vikings sent a handful of their powerful elites to the afterlife in boats laden with sacrificed animals, weapons and treasure; the funeral practice dates back to the Iron Age (A.D. 550 to 800) but was used throughout the Viking age (A.D. 800 to 1050), according to a statement. These richly appointed graves have been discovered across Scandinavia. For example, archaeologists had previously found one such burial boat in Norway that had evidence of human remains and one in western Scotland that contained a slew of burial items such as an ax, a shield boss, a ringed pin, a hammer and tongs. The elites who were given such elaborate send-offs were also often buried with animals, such as stallions.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65892-viking-burial-boats-discovered-sweden.html?jwsource=cl已复制直播00:0000:3500:35  These burial boats were typically built with overlapping wooden planks (called “clinker built”) and had symmetrical ends, a true keel and overlapping planks joined together, said Johan Anund, the regional manager for The Archaeologists, an archeological organization working with the National Historical Museums in Sweden. Archaeologists have also found other, simpler boat structures, such as logboats, which are like a dugout wide canoe, Anand told Live Science in an email. [Photos: A Man, a Horse and a Dog Found in Viking Boat Burials] The remains of the dog and the horse were nestled in the bow of the well-preserved boat, while the remains of the man were found in the stern. “We don’t know much” about the man yet, Anund said. But analysis of the skeleton will reveal how old he was, how tall he was and if he had any injuries or diseases. Anund’s group may even be able to figure out where the man grew up and where he lived for most of his life, Anund said. As for the animals buried with him, they could have been sacrificed to help the dead person on the “other side” but could also be there to show the man’s status and rank, Anund said. It’s common to find horses and dogs in such burials, but also big birds like falcons. Archaeologists also found other items on the boat such as a sword, spear, shield, an ornate comb, and leftover wood and iron nails that were likely used in its construction. The other boat was badly damaged, probably because a 16th-century medieval cellar was built right on top of it, according to the statement. Some human and animal bones were still preserved on the damaged ship, but they seem to have been moved around, making it difficult for archaeologists to say much about them, Anund said. Archaeologists discovered the ships, the well and the cellar after a plot of land outside Uppsala was marked off to become a new building for the vicarage of Gamla Uppsala parish. They excavated the boats last month and some of the finds will go on display at Gamla Uppsala museum and the Swedish History Museum in Stockholm. Live Science Editor-in-Chief Jeanna Bryner contributed to this story. Editor’s Note: This article was updated to correct the fact that “clinker” boats meant the boats were made of overlapping wooden planks. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeDugiFeedThis Is What Will Happen When You Eat Bananas Every DayDugiFeedUndoBrilliant Future10 Worst Paying College MajorsBrilliant FutureUndoMy Daily DiscoveryHow To Keep Your Photos And Videos SafeMy Daily DiscoveryUndoThe SideHairstyles That Make You Look Younger Than EverThe SideUndoeasyrecipes20 Toughest Restaurants Worldwide To Get A Reservation (But Worth The Wait)easyrecipesUndoComparisons.orgCalifornia Drivers With No Tickets In 3 Years Must Read ThisComparisons.orglast_img read more

Johor DOE raids three illegal factories in Pasir Gudang

first_img Nation 08 Jul 2019 Round-the-clock air quality monitoring at Pasir Gudang schools {{category}} {{time}} {{title}} “One factory was believed to be recycling used items such as plastics and oil. Another was dealing with metals and the third was separating solid wastes,” he told Bernama on Friday (July 12).As of 5pm on July 11, the integrated operation which included various government agencies like the DoE and the MPPG inspected 248 factories.Also in the raiding party were Energy, Science, Technology, Environment and Climate Change Minister Yeo Bee Yin and chairman of the state Local Government, Urban Wellbeing and Environment Committee Tan Cheng Choon.Wan Abdul Latiff said 125 compounds were issued for disposal of scheduled wastes, 10 for industrial effluents and one for sewage plant.He added that although the initial target of inspecting 250 factories was almost achieved, the department would continue with more inspections.”We will continue to conduct as many (checks on factories) as possible. I want to do more (than 250 factories),” he said.According to a posting on the DoE account on Facebook on July 11, the focus of the operations was on illegal factories.Besides the stop-work order, other action taken against these factories included cutting off electricity supply. – Bernama JOHOR BARU (Bernama): Three factories believed to be operating illegally in Pasir Gudang were raided and action taken against them by enforcement authorities in an integrated operation.This followed the recent incident where residents suffered breathing difficulties and vomiting.Director of the Johor Department of Environment (DOE) Wan Abdul Latiff Wan Jaafar said the operation by various agencies on Thursday (July 11) halted the operations of these factories, with equipment in one factory confiscated. The Pasir Gudang Municipal Council (MPPG) also sealed off the three factories. Nation 11 Jul 2019 Why buy unsuitable gas detectors for Pasir Gudang, asks Wanita MCAcenter_img Related News Related News Nation 11 Jul 2019 DOE’s gas detectors not suitable for schools, says MCAlast_img read more