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DONEGAL RAILWAY SHOW LEAVES THE STATION TODAY!

The Letterkenny model from track level inside the real Coach 58The Railway Show season is starting in Donegal Town and will make a welcome relief from the overload of politics and not so sunny climates!Donegal Railway Heritage Centre is holding its first model railway exhibition of the year from today, Saturday, May 24 through to Monday, May from 12 noon to 5pm each day.There will be working scale models of the old County Donegal Railway stations at Letterkenny and Donegal Town, each assembled in different coaches from the original Donegal rolling stock. There will be an OO gauge layout in the original passenger trailer No 5. There will also be working displays of old Hornby O Gauge tinplate trains in both electric and clockwork, some of these being up to 90 years old.There will also be a Meccano and Dinky Toy display and films of the old railways of the County when they were running. Weather permitting, there will be train rides for children on a miniature railway and the garden railway will be in operation.Meanwhile the County Donegal Railway Restoration Ltd will be holding its AGM in the McGowan Room, one of the railcar trailers on the railway, at the Donegal Railway Heritage Centre today at 2pm.At the end of the AGM, around 3pm, there will be a book launch open to the public – this will be a revised and updated edition of the key reference work on the County Donegal Railway and one of the co-authors will be present to sign copies. This should make excellent reading for anyone with any interest in the story of the railways around Donegal or those who remember the railway and any elderly relatives.To complete a busy time for the railway, the company is also recruiting, see below, and CVs can be handed in from now up to the end of the show on May 26.Railway Situation VacantCounty Donegal Railway Restoration Ltd needs staff to assist the Donegal Railway Heritage Centre in developing and maintaining its buildings and displays and in increasing its revenue.The work involves a variety of fund-raising and sales tasks, assisting at shows, document design and other computer tasks, and basic maintenance of the displays in running order, plus some housekeeping of these to ensure the museum is kept impressive for visitors, and displays are refreshed and changed. As the wages are funded through Pobal preference will be given to those currently on the unemployment list, recently laid off or who have special needs. Send CV or hand in at the address below. Excellent references needed. Closing date May 26.More information from: The Manager, Donegal Railway Heritage Centre, Tyrconnell St, Donegal Town. Telephone: (074) 9722655DONEGAL RAILWAY SHOW LEAVES THE STATION TODAY! was last modified: May 24th, 2014 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:donegalRailway Show read more

Brand South Africa calls on citizens for humanitarian support following a massive fire in Alexandra

first_imgJohannesburg, Friday, 07 December 2018 – Brand South Africa calls on citizens for humanitarian support following a massive fire in Alexandra (Alex) on Thursday, 06 December 2018. The Johannesburg emergency services managed to distinguish the blaze preventing further damage to the area.The fire has displaced hundreds of people, according to emergency services spokesperson, Nana Radebe, “at least 500 shacks have been destroyed, leaving 150 families displaced”.Brand South Africa calls on all to unite, play their part and assist with providing humanitarian support in the form of food, water, shelter which can be delivered to Alex and the Sandton fire station. It is imperative now more than ever to be reminded that “a nation’s greatness is measured by how it treats its weakest members.”Brand South Africa applauds Gift of the Givers who are on site in Alex providing aid and have moved a mother who gave birth yesterday and another with four children who lost everything in the fire, to their Logistics Centre in Bramley.In a statement Gift of the givers said; “our teams are registering the rest of the victims and transporting them to a nearby hall where we are providing food, bottled water, blankets and mattresses. During the course of today, further appropriate interventions will be effected”.Gift of the Givers on-site contact person, Emily Thomas 083 652 0315.last_img read more

Woot + Amazon = Real-Time Social Shopping

first_imgmarshall kirkpatrick Related Posts A Web Developer’s New Best Friend is the AI Wai… Tags:#Analysis#NYT#web Shopping giant Amazon bought online auction phenomenon Woot today, and given the relative sizes of the companies, it can only be a move made with long-term Amazon strategy in mind. Earlier this afternoon we wrote about the deal as a victory for freaks and a marriage of light- and heavy-weight supply chains, but there’s something else going on here, too.Woot is bringing real-time social shopping to Amazon. We pinged ReadWriteWeb reader Michael Vorel, the CEO of commerce, Internet marketing and consulting company Vastplanet for a brief comment, and he argued that this was a competitive move against the coming media convergence that will pit Amazon against TV shopping networks.Vorel:“It’s an excellent move by Amazon. Amazon needed something that was real-time shopping, in the sense of a QVC or HSN [Home Shopping Network]. It gives Amazon the opportunity to tie together with existing retailers into a daily special. With the infrastructure and connections Amazon has, it could tap into these two communities to offer better pricing and a more successful operation. Top Reasons to Go With Managed WordPress Hosting Compete says Woot got 2.2 million unique visitors in May. Facebook referred 10.5% of that traffic, so it extends far out into social media.”“The emergence of social shopping is evident in Woot, very similar to the special of the day on HSN. Amazon is looking for unique properties that fit the social shopping model that they can bring under their umbrella. “Compete says Woot got 2.2 million unique visitors in May. Facebook referred 10.5% of that traffic, so it extends far out into social media. “I think what we’re going to see from Woot is, we’ll see more interesting products roll through and maybe a hint of more categories per day. You could have a channel where you had it by category, Mens items, Women’s items, etc. That would allow a lot more people to play within Woot and a lot more money to be made. “The products they [Woot] are selling are so slim margin, they needed to look at other ways to make money. Someone like Amazon could look at behavioral learning techniques, they could learn how to serve those people. I think it’s very interesting that both Zappos and Woot were big social media ecommerce companies and both were acquisitions.”That sounds like a pretty smart take on the deal to me. Woot says it will maintain its functional independence, but there’s got to be some cultural cross-pollination in the plans. As media convergence brings Amazon into direct competition with at-home TV shopping, what better way to gear up than with one of the new geniuses of real-time social shopping, Woot? 8 Best WordPress Hosting Solutions on the Market Why Tech Companies Need Simpler Terms of Servic…last_img read more

Mavericks stop 4-game slide with win against Bucks

first_imgKidd said his team should have been ready for the 3-point barrage.“Coming into the game we had talked about how they are second in the league in attempts,” Kidd said. “They just haven’t made them. But tonight they made up for all those misses.”Milwaukee went 6 of 25 from 3-point range.TERRY RETURNSJason Terry played the final couple minutes for Milwaukee and got a standing ovation from the crowd. The 40-year-old Terry played for Dallas from 2004 to 2012 and helped the Mavs win the NBA title in 2011.Terry scored on his only field-goal attempt, leading to a large roar from the crowd.“I knew he was gonna score,” Mavericks coach Rick Carlisle said. “I was gonna clap, I wasn’t sure how appropriate that was. You know how I feel about him, that’s one of the reasons we’re all wearing rings here.”TIP-INSBucks: C John Henson went 3 for 10 at the free-throw line. … Kidd had two stints in Dallas as a player and averaged 10.5 points, 5.5 rebounds, and 8.4 assists in 500 career games with the Mavericks. … The Bucks host the Mavericks on Dec. 8.Mavericks: C Nerlens Noel only played three minutes. Noel played six minutes in Friday night’s 111-87 loss to Minnesota and has been replaced in the rotation by Salah Mejri. … Dallas still leads the NBA with 14 losses this season. View comments Milwaukee had won four in a row. Giannis Antetokounmpo had 24 points and 17 rebounds for the Bucks (8-7), and Khris Middleton added 23 points.It was Milwaukee’s first loss since it acquired Eric Bledsoe in a trade with the Phoenix Suns on Nov. 7.“I think the ball was just stuck,” Bucks coach Jason Kidd said. “The ball got sticky and we were afraid to let go of it to a teammate.”The Mavericks never trailed after Matthews’ 3-pointer made it 22-20 with 3:07 left in the first quarter. Dallas went 19 for 38 from beyond the arc, including a shot clock-beating 3 from near midcourt by Barea that made it 88-64 in the fourth quarter.“I had to shoot that one,” Barea said. “You don’t see a lot of those.”ADVERTISEMENT Japan ex-PM Nakasone who boosted ties with US dies at 101 UP NEXTBucks: Host the Washington Wizards on Monday.Mavericks: Host the Boston Celtics on Monday. LATEST STORIES Kammuri turning to super typhoon less likely but possible — Pagasa Typhoon Kammuri accelerates, gains strength en route to PH Dallas Mavericks’ Dirk Nowitzki (41), of Germany, shouts at an official calling for a foul after attempting a shot in the first half of an NBA basketball game against the Milwaukee Bucks, Saturday, Nov. 18, 2017, in Dallas. (AP Photo/Tony Gutierrez)DALLAS — The Dallas Mavericks’ first win in a couple weeks was quite a relief for Wesley Matthews and company.Matthews scored a season-high 22 points, and the Mavericks stopped a four-game slide with a 111-79 victory over the Milwaukee Bucks on Saturday night.ADVERTISEMENT CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Kris Aquino ‘pretty chill about becoming irrelevant’center_img MOST READ Stronger peso trims PH debt value to P7.9 trillion “It rejuvenates you,” Matthews said. “Everybody feels good. Aches don’t hurt as much, you just feel better about everything you’ve done. You don’t need moral victories, you’ve got the real one and you can actually see everything we’re trying to bring together.”Matthews also had eight assists while helping Dallas (3-14) to its first win since Nov. 7 at Washington. He had six of the Mavericks’ franchise record-tying 19 3-pointers.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout“We were playing basketball, and one of the hardest things to guard is random movement,” he said. “That’s when I’m at my best, when we’re just playing and stay in a rhythm.”J.J. Barea had 20 points for the Mavericks, and Harrison Barnes finished with 18. Yogi Ferrell had 16 points and Dwight Powell grabbed 13 rebounds. Brace for potentially devastating typhoon approaching PH – NDRRMC Harden scores 29 to lead Rockets past Grizzlies Trending Articles PLAY LIST 00:50Trending Articles02:29Giannis Antetokounmpo powers Bucks in bounce back win over Celtics00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Read Next Don’t miss out on the latest news and information. QC cops nab robbery gang leader, cohortlast_img read more

SEA Games: Suarez, two Filipino pugs enter semis; Paalam out

first_imgLacson: SEA Games fund put in foundation like ‘Napoles case’ Robredo should’ve resigned as drug czar after lack of trust issue – Panelo Fil-Briton Felix John Nobel Tupas finished the card with a dominant debut for the Philippines team in 81kg, banging Cambodian Felix Merlin Martinez via unanimous decision.READ: ‘Solid’ PH boxing team capable of taking home golds But the victories were tinged by the questionable defeat of Carlo Paalam to Malaysian Muhamad Fuad Redzuan in the 49kg.Paalam, one of the most promising boxers in the country at only 19 years old, was clearly on top of everything against the fighter who had earlier in his career lost to Filipinos Rogen Ladon and Elmer Pamisa.But Redzuan kept Paalam busy by dragging him down at least four times throughout the match.ADVERTISEMENT LATEST STORIES PH men’s volley team drops SEA Games opener to Vietnam Celebrity chef Gary Rhodes dies at 59 with wife by his side “I told myself that I need to win the favor of the crowd,” said Suarez in Filipino who unloaded his power punches that put Azmi on all fours. The Malaysian, though, made the count.READ: PH boxers make rousing 2017 SEA Games debutsFEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingMario Fernandez also advanced after a masterful unanimous decision win over Tran Phu Masuk of Vietnam in the 56kg.Fernandez, the defending champion in bantamweight division, controlled the match with his 1-2 combinations. READ: PH in for tough gold hunt in SEA Games; Athletics, boxing bright spotsThe Malaysian also threw haymakers coming from out of nowhere and landing very few.That decision shocked the Philippine team here drawing criticism as the Malaysian Sports Minister Brig. Gen. Khairy Jamaluddin Abu Bakar was in the sidelines.Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. Trending Articles PLAY LIST 00:50Trending Articles02:49World-class track facilities installed at NCC for SEA Games03:07PH billiards team upbeat about gold medal chances in SEA Games05:25PH boxing team determined to deliver gold medals for PH03:04Filipino athletes share their expectations for 2019 SEA Games00:45Onyok Velasco see bright future for PH boxing in Olympics02:25PH women’s volleyball team motivated to deliver in front of hometown crowd01:27Filipino athletes get grand send-off ahead of SEA Games00:36Manny Pacquiao part of 2019 SEA Games opening ceremonycenter_img Charly Suarez of the Philippines dominates Khir Akyazlan Bin Azmi of Malaysia in the quarterfinals of the light welterweight class men’s boxing competition of the 29th Southeast Asian Games at the MITEC Hall 8 in Kuala Lumpur. Suarez prevailed by unanimous decision. CONTRIBUTED PHOTO/SEA GAMES POOLKUALA LUMPUR — Two-time champion Charly Suarez battered Malaysia foe to score a convincing decision win and lead two other Filipino boxers to the Southeast Asian Games semifinals at MITEC Hall 8.Suarez slammed left and right upper cuts to the solar plexus of Khir Akyazlan Azmi in the third to win the 64kg quarterfinal match before a band of uniformed, boisterous crowd trying to distract the Filipino.ADVERTISEMENT MOST READ Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Pagasa: Storm intensifies as it nears PAR NATO’s aging eye in the sky to get a last overhaul Hotel says PH coach apologized for ‘kikiam for breakfast’ claim Trump signs bills in support of Hong Kong protesters View commentslast_img read more

Lovett Looking Forward To Coaching Role

first_imgNine debutants will take to the field for Australia at an Open level for the Mixed side in the Trans Tasman Test Series against New Zealand which starts tonight at Mudgee’s Glen Willow Regional Sporting Complex. Despite only six players still in the side following Australia’s 2011 World Cup final defeat over New Zealand, Lovett is confident his team has what it takes to continue Australia’s recent strong record over the Kiwis in the Mixed division. “Most of them are coming out of our Youth program and our Youth program has been quite strong since it was rebuilt after the 2005 Youth World Cup that we lost.”“They are new to Open’s but they’ve played international Touch before and they’ve come from some very good programs in their regional level and even their club based stuff. It’s actually quite a very good balance for me, there are some young players that are coming through, probably the one that is really a debutant is Michael Law. He’s a bit of an excitement machine, he’s super fast, he’s very agile, he reads the game well. He’s going to be a player to watch once he finds his feet at that level,” Lovett said. Lovett started his coaching career close to 20 years ago and in recent times has coached the Australian 20’s Boys at the 2009 Youth Trans Tasman Series as well as being the Australian Women’s Open assistant coach for the 2009 and 2010 Trans Tasman events as well as the 2011 World Cup. Lovett says that it’s been a long pathway to get to where he has, but he can’t wait to take on the Kiwis from Thursday.“I’m pretty excited. Coming from a developing state (Victoria) it’s a massive honour, things are a little bit different when you don’t come from Queensland or New South Wales so you have to get up a little earlier and work a little bit harder to keep up on your skills and the modern trends of the sport because it’s not directly at your back door.”“I think both the roles I’ve had in the past four years have been pretty important, with the Men’s 20’s and the Women’s Open because obviously it’s a crossover between both the girls and guys and stepping into Mixed is a new arena for me.”“The Open’s Women’s was good exposure to the pointy end of the sport, I got to work with some really good athletes in the Women’s program and some coaches who have been around for a long period of time as well in Kerry (Norman) and Dean (Russell). Both of them have helped hone and develop my skills as I’ve come through as well as my other mentors, so it’s been good.”Mixed specialist Manu Wakely is Lovett’s assistant coach for the series, with Wakely’s experience  in the Mixed arena both as a player and as a coach to be invaluable for the side. “I’m looking forward to working with Manu Wakely, he’s been a very successful Mixed coach and loves the detail, he pretty much lives and breathes Touch so it’s great to work with Manu and see his passion for the game.”Lovett says he will be looking to the more experienced players in his team, including co-captain’s Kylie Hilder and Rohit Prasad as well as Jamie Chan and Sarah Spacie, to guide the debutants along the way in the Series. Seeing some of his Australian 20’s Boys side from the 2009 Youth Trans Tasman progress into the Mixed Open side will also be an exciting prospect for Lovett, as well as unleashing a few new faces against New Zealand for the first time. “I’m looking forward to building a new team together with the senior playing group and fostering some of the development of some of the 20’s Boys I’ve brought through and exposing some of the new players we have like Peter Watkins, it will be exciting.”“We’ve got a strong side that has a lot of potential, but we’ve got to live up to our potential and deliver on the park. It’s their opportunity now to basically come to the international stage and try to deliver, and some of the young kids, seeing someone like Michael Law getting his opportunity being able to apply his trade at this level and how he takes that into the Youth programs going forward is exciting.”There are plenty of ways to keep in touch with the 2012 Trans Tasman Series, which will be held at Mudgee’s Glen Willow Regional Sporting Complex from Thursday, 26 April to Saturday, 28 April 2012, including in the following ways: Websites: www.austouch.com.au www.transtasman.mytouchfooty.com Facebook – www.facebook.com/touchfootballaustralia Twitter – www.twitter.com/touchfootyaus (be sure to use the hashtag #transtasman2012 in your tweets) YouTube – www.youtube.com/touchfootballauslast_img read more

20 days agoLeeds to cut short loan of Tottenham midfielder Jack Clarke

first_imgLeeds to cut short loan of Tottenham midfielder Jack Clarkeby Paul Vegas20 days agoSend to a friendShare the loveLeeds United are set to cut short the loan of Tottenham midfielder Jack Clarke.The Sun says the 18-year-old was loaned back to Elland Road after his £10million move to Spurs – but has not made a Championship appearance.And Marcelo Bielsa will have £10,000-a-week off the wage bill and a place in his squad when Clarke’s season-long deal is cut short.Bielsa is set to look for a loan signing to add competition for his first team for the second half of the season as the club battle for promotion. TagsTransfersLoan MarketAbout the authorPaul VegasShare the loveHave your saylast_img

Rep Brann votes to lower car insurance rates for Michigan drivers

first_img Categories: Brann News 09May Rep. Brann votes to lower car insurance rates for Michigan drivers State Rep. Tommy Brann today voted to approve a landmark plan to fix Michigan’s broken car insurance system and reduce rates for drivers all across the state.Brann said the plan offers drivers personal injury coverage options, reins in medical costs and fights fraud – reforms designed to end Michigan’s long-standing tenure as the state with the highest car insurance rates in the nation.Michigan is the only state to mandate unlimited lifetime health care coverage through car insurance. The plan approved today allows people currently using the coverage to keep it, and those who want it in the future to continue buying it – while providing more affordable options.“This is one of the issues I hear about most from people in our community,” Brann, of Wyoming, said after the vote. “I’m glad we were able to deliver a solution that lowers rates. I fought hard to keep the option to continue purchasing coverage that provides unlimited lifetime health care if they are injured in a car crash. This was not in the Senate bill and is important to me. This is the option my wife and I will be selecting – and I hope others will seriously consider it as well – but people deserve to weigh their options.”The plan:Guarantees lower personal injury protection rates for all Michigan drivers;Gives drivers a choice on car insurance policies;Stops potential price gouging on medical services for car accident victims;Combats fraudulent claims to help lower costs.The sweeping legislation now advances to the Senate for consideration.###last_img read more

Molecular signatures reveal why women are more likely to die from glioblastoma

first_imgIt is our expectation that this study could have an immediate impact on the care of patients with glioblastoma and further research. The findings indicate we should be stratifying male and female glioblastoma into risk groups and evaluating the effectiveness of treatment in a sex-specific manner.”Dr. Joshua Rubin, Co-senior Author Giovanni Cancemi | ShutterstockThe team identified distinct molecular signatures in tumors taken from men and women that helped to explain the disparity in treatment and survival rates.The study suggests that tailoring treatments based on the molecular subtype of men and women’s tumors may improve patient outcome. In a study of adults with glioblastoma, Dr. Joshua Rubin and colleagues found that women responded better to treatment than men.To investigate why, they used standard MRI scans to measure tumor growth velocity, enabling them to derive a value for how quickly tumors were growing.As reported in the journal Science Translational Medicine, the team then pulled patients’ MRI scan and survival data from a cancer research database and assessed tumor growth velocity every two months among 40 males and 23 females who received standard chemo-radiation therapy after they had undergone surgery.”The males did not respond as well, and we wanted to understand why, so we looked at the underlying genetics of patients’ tumors,” says Rubin.The researchers tapped into The Cancer Genome Atlas and applied advanced statistical algorithms that would distinguish male- or female-specific gene expression patterns from such patterns that were shared among the male and female patients.They then looked at sex-specific gene expression to find molecular subtypes that would correspond with the differences seen in male and female survival.Co-senior author Jingqin Luo says: “We observed tremendous genetic sex differences in the tumors of glioblastoma patients that correlated with survival.”The team found that tumors were clustered into five subtypes in males and five in females. Females with tumors from one cluster survived just over three years compared with just over one year among females with tumors from any of the other four clusters.Similarly, men with tumors from one cluster survived just over 18 months compared with just over one year among men who had tumors from the other four clusters.The team also identified genetic pathways that correlated with the longest survival and they were very different in males compared with females, says Rubin. For example, survival among males was partially dependent on the regulation of cell division, suggesting that medication to block the cell cycle may be more effective in men.Among women, survival was affected by regulation of invasiveness, indicating that targeting integrin signaling may be the most effective approach. This tells us it might be better to separate males and females and examine their sex-specific genetic signatures.”Joshua Rubin, Co-senior Authorcenter_img By Sally Robertson, B.Sc.Jan 2 2019Reviewed by Kate Anderton, B.Sc. (Editor)A study led by researchers at the Washington University School of Medicine has shed light on why more males than females develop and die from the deadly brain cancer, glioblastoma. SourceSex differences identified in deadly brain tumors.last_img read more

Innovative membrane offers a viable solution for periodontitis

first_img Source:http://newsroom.ucla.edu/releases/new-class-membranes-regenerate-tissue-bone-periodontitis Reviewed by James Ives, M.Psych. (Editor)Mar 22 2019Periodontitis affects nearly half of Americans ages 30 and older, and in its advanced stages, it could lead to early tooth loss or worse. Recent studies have shown that periodontitis could also increase risk of heart disease and Alzheimer’s disease.A team of UCLA researchers has developed methods that may lead to more effective and reliable therapy for periodontal disease — ones that promote gum tissue and bone regeneration with biological and mechanical features that can be adjusted based on treatment needs. The study is published online in ACS Nano.Periodontitis is a chronic, destructive disease that inflames the gums surrounding the tooth and eventually degrades the structure holding the tooth in place, forming infected pockets leading to bone and tooth loss. Current treatments include infection-fighting methods; application of molecules that promote tissue growth, also known as growth factors; and guided tissue regeneration, which is considered the optimal standard of care for the treatment of periodontitis.Guided tissue regeneration, in the case of periodontitis, involves the use of a membrane or thin film that is surgically placed between the inflamed gum and the tooth. Membranes, which come in non-biodegradable and biodegradable forms, are meant to act not only as barriers between the infection and the gums, but also as a delivery system for drugs, antibiotics and growth factors to the gum tissue.Unfortunately, results from guided tissue regeneration are inconsistent. Current membranes lack the ability to regenerate gum tissue directly and aren’t able to maintain their structure and stability when placed in the mouth. The membrane also can’t support prolonged drug delivery, which is necessary to help heal infected gum tissue. For non-biodegradable membranes, multiple surgeries are needed to remove the membrane after any drugs have been released — compromising the healing process.”Given the current disadvantages with guided tissue regeneration, we saw the need to develop a new class of membranes, which have tissue and bone regeneration properties along with a flexible coating that can adhere to a range of biological surfaces,” said Dr. Alireza Moshaverinia, lead author of the study and assistant professor of prosthodontics at the UCLA School of Dentistry. “We’ve also figured out a way to prolong the drug delivery timeline, which is key for effective wound healing.”The team started with an FDA-approved polymer — a large-scale synthetic molecule commonly used in biomedical applications. Because the polymer’s surface isn’t suitable for cell adhesion in periodontal treatment, the researchers introduced a polydopamine coating — a polymer that has excellent adhesive properties and can attach to surfaces in wet conditions. The other benefit of using such a coating is that it speeds up bone regeneration by promoting mineralization of hydroxyapatite, which is the mineral that makes up tooth enamel and bone.Related Stories’Text neck’ may be causing bone spurs in young peopleResearchers describe how prostate cancer cells develop ability to mimic osteoblastsEngineered stem cells offer new treatment for metastatic bone cancerAfter identifying an optimal combination for their new membrane, the researchers used electrospinning to bond the polymer with the polydopamine coating. Electrospinning is a production method that simultaneously spins two substances at a rapid speed with positive and negative charges, and fuses them together to create one substance. To improve their new membrane’s surface and structural characteristics, the researchers used metal mesh templates in conjunction with the electrospinning to create different patterns, or micro-patterning, similar to the surface of gauze or a waffle.”By creating a micro pattern on the surface of the membrane, we are now able to localize cell adhesion and to manipulate the membrane’s structure,” said co-lead author Paul Weiss, UC presidential chair and distinguished professor of chemistry and biochemistry, bioengineering, and materials science and engineering at UCLA. “We were able to mimic the complex structure of periodontal tissue and, when placed, our membrane complements the correct biological function on each side.”To test the safety and efficiency of their new membrane, the researchers injected rat models with gingival-derived human stem cells and human periodontal ligament stem cells. After eight weeks of evaluating the degradation of the membranes and the tissue’s response, they observed that the patterned, polydopamine-coated polymer membrane had higher levels of bone gain when compared to models with no membrane or a membrane with no coating.In order to suit a wide range of medical and dental applications, the researchers also figured out a way to adjust the speed at which their membranes degraded when inserted in their models. They did this by adding and subtracting different oxidative agents or using lighter polymer bases before going through the electrospinning process. The ability to turn the degradation rates up or down helped the researchers control the timing of the delivery of drugs to the desired areas.”We’ve determined that our membranes were able to slow down periodontal infection, promote bone and tissue regeneration, and stay in place long enough to prolong the delivery of useful drugs,” Moshaverinia said. “We see this application expanding beyond periodontitis treatment to other areas needing expedited wound healing and prolonged drug delivery therapeutics.”The researchers’ next steps are to evaluate whether their membranes can deliver cells with growth factors in the presence or absence of stem cells.last_img read more